Enclomiphene, or enclomiphene citrate, is an oral medication that helps restore natural testosterone production in men with a form of low testosterone called secondary hypogonadism by signaling the body to make more testosterone and sperm. It supports healthy hormone levels without suppressing sperm count, making it a fertility-friendly option for men with low testosterone.1
1. Thomas, J., Suarez Arbelaez, M. C., Narasimman, M., Weber, A. R., Blachman-Braun, R., White, J. T., Ledesma, B., Ghomeshi, A., Jara-Palacios, M. A., & Ramasamy, R. (2023). Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus, 15(7), e41476. Source.
There is limited research on the side effects of enclomiphene. Common side effects include headache, hot flashes, mood changes or irritability, nausea or upset stomach, breast tenderness, and fatigue.
If you notice any serious side effects, seek medical care immediately. These include vision changes, floaters, or vision loss; severe or persistent headaches; signs of blood clots (leg swelling, chest pain, shortness of breath); mood changes, depression, mania, or new psychiatric symptoms; signs of liver problems (yellowing skin/eyes, dark urine, abdominal pain); swelling, rapid weight gain, or fluid retention; polycythemia; and new or worsening cancer symptoms.
Yes, enclomiphene increases testosterone levels in men with secondary hypogonadism by stimulating the body’s natural testosterone production. It’s an effective option for restoring testosterone while maintaining fertility2 and supporting natural sperm production.
2. Thomas, J., Suarez Arbelaez, M. C., Narasimman, M., Weber, A. R., Blachman-Braun, R., White, J. T., Ledesma, B., Ghomeshi, A., Jara-Palacios, M. A., & Ramasamy, R. (2023). Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus, 15(7), e41476. Source.
Enclomiphene has not been studied extensively, but in one study, it was shown to increase total testosterone levels in men with secondary hypogonadism in as little as two weeks. The study was a randomized study of enclomiphene citrate in 44 men with secondary hypogonadism for 6 weeks.3
3. Wiehle, R., Cunningham, G. R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G. K., Rosner, M., Dwyer, A., & Podolski, J. (2013). Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU international, 112(8), 1188–1200. Advance online publication. Source.
No, enclomiphene is not FDA-approved and has not been evaluated for safety, effectiveness, or quality. While clomiphene is approved by the U.S. Food and Drug Administration (FDA) for use in women, enclomiphene remains investigational and is only available through compounding pharmacies or clinical trials.
Enclomiphene is not known to cause hair loss directly, and hair loss is not listed among the medication’s reported side effects.
Hims offers access to a daily oral medication that contains just enclomiphene or combines enclomiphene with tadalafil. The medication containing tadalafil offers a treatment plan for patients with a clinical need to boost testosterone production and help with erectile function. Treatments are offered in 3-, 5-, or 10-month plans.
To start low testosterone treatment through Hims, you’ll have a consultation with a licensed healthcare provider. You’ll be guided through lab testing to assess your testosterone levels and determine whether you have a testosterone deficiency. If eligible, a treatment plan—such as enclomiphene—will be prescribed and shipped directly to you. Does Hims offer access to testosterone replacement therapy (TRT) injections? Why am I required to conduct lab testing? How will I know if I’m eligible for medication? How do I receive and complete my at-home labs? Why do I need to ship my samples back the same day I collect them? If eligible, how much does Testosterone Rx treatment cost? Are video visits with a doctor required? Is insurance required? Can I pay with an FSA or HSA?
No, Hims does not currently offer access to TRT injections.
The lab test is ordered by a healthcare provider as part of your visit. It doesn’t diagnose conditions, but it’s essential for measuring your baseline testosterone levels, assessing for testosterone deficiency, and determining if you’re eligible for treatment. Monitoring levels also helps ensure appropriate dosing and tracks improvement in your health over time.
Eligibility is determined based on your lab results and medical evaluation. A healthcare provider will review your total testosterone, hormone levels, and any symptoms of low testosterone, like decreased libido, erectile dysfunction, or mood changes, before prescribing any medication.
As part of your visit, a healthcare provider will order labs processed in a CLIA-certified lab, which is required to determine your eligibility for treatment. Through Hims, you can complete your labs from the comfort of home.
You’ll check out with an initial at-home Hims Labs kit, which will be sent directly to your doorstep. The kit comes with everything you need to take your blood samples at home, along with detailed, step-by-step instructions to help guide you. You’ll collect two samples and send them to the lab for analysis using the same packaging your kit came in and a convenient prepaid return label.
For an accurate lab reading and to avoid a redo, ship your samples via FedEx the same day you collect them—just use the prepaid shipping label included in your kit.
Pricing for low testosterone treatment with enclomiphene through Hims starts at $99/month for a 10-month plan paid upfront and in full.
In some states, a video visit with a healthcare provider is required. If you live in one of these states, you’ll be prompted to schedule a video visit after receiving your lab results.
Insurance isn’t required, so there are no complicated insurance questions or health insurance plan considerations.
Hims & Hers doesn’t take FSA or HSA plans as payment at this time.
